New Research Links Ozempic to Potential Hair Loss: What You Need to Know

Loss of hair can be a troubling experience, especially for those taking weight loss medications like semaglutide, the active ingredient in Ozempic and Wegovy. Recent studies indicate that individuals using semaglutide may be at risk for hair loss, prompting concerns and inquiries into how to mitigate this side effect while still achieving weight loss goals. Understanding the link between semaglutide, rapid weight loss, and hair health is essential for those considering or currently using these medications.

A significant study conducted by researchers at the University of British Columbia (UBC) revealed that individuals taking semaglutide experienced more hair loss compared to those on alternative weight loss drugs, specifically bupropion-naltrexone. This finding, although still preliminary, suggests that the physiological changes associated with rapid weight loss could explain these adverse effects.

“There were many anecdotal reports, case studies, and reports to the FDA of hair loss, but no studies investigated this risk in a real-life clinical setting,” said Dr. Mohit Sodhi, the primary author of the study.

Comparative Analysis of Medications and Hair Loss

The UBC study assessed the health records of 1,926 individuals taking semaglutide for weight loss, excluding those with diabetes or antihyperglycemic treatments. A comparator group of 1,348 individuals was analyzed, who were on bupropion-naltrexone, sold as Contrave.

Dr. Sodhi noted, “Bupropion-naltrexone was used as an active comparator because it is chemically distinct from semaglutide, which helps control for confounding by indication.” The findings showed that:

• The incidence of hair loss diagnosis was 26.5 out of 1,000 for those on semaglutide.
• In contrast, it was 11.8 out of 1,000 for those taking bupropion-naltrexone.
• Women experienced a more than doubled risk of hair loss compared to men.

“Our results were validated by the Wegovy clinical trials, which showed a similar risk ratio to our study,” Dr. Sodhi added.

Understanding Hair Loss in GLP-1 Patients

Doctors who work with patients using GLP-1 medications, including semaglutide, report frequent instances of hair-related side effects. Dr. Saami Khalifian, a double board-certified dermatologist, noted, “This rapid type of hair loss is something we commonly see in GLP-1 patients.”

He described hair loss due to a condition called telogen effluvium, which can occur as a response to physiological stress. Other medical professionals have similarly observed hair loss as a common concern among their patients on GLP-1 medications

“Next to constipation and diarrhea, it’s probably the top concern people have,” stated Dr. Brynna Connor, a board-certified family medicine physician.

Potential Causes of Hair Loss Linked to Semaglutide

While the exact mechanisms are not fully understood, the theory posits that rapid weight loss rather than semaglutide itself triggers hair loss. This phenomenon might be due to:

• The physiological stress associated with rapid weight changes, disrupting the natural hair cycle.
• The effect of semaglutide on appetite, leading to reduced food intake, potentially resulting in nutrient deficiencies.

Dr. Sodhi remarked, “One factor could be the physiological stress that rapid weight loss can induce, leading to a disruption of the natural hair cycle.” Major life changes or stressors, like pregnancy or severe illnesses, are also linked to temporary hair loss.

Strategies to Minimize Hair Loss While Using GLP-1 Medications

To help maintain hair health while taking GLP-1 medications, here are some effective strategies:

• Prioritize Protein: Front-load meals with protein to ensure adequate intake. Dr. Khalifian advises, “Eat the protein first; by the time you get to the carbs, you might be full.”
• Consider Supplementation: If dietary intake is insufficient, consider supplements like biotin, which is known to promote stronger hair, skin, and nails.
• Topical Treatments: Products like minoxidil can stimulate hair growth and may be an option for individuals concerned about hair loss.

Before starting any GLP-1 medication, Dr. Connor suggests getting lab work done to rule out underlying conditions that could contribute to hair loss, such as anemia or thyroid disorders. If hair loss is a concern, collaborating with a dietitian to create a balanced nutrition plan is advisable.

“Everything you put in your body counts even more, so it’s vital to eat nutritious food,” emphasized Dr. Connor.

Consulting with a healthcare provider is crucial for understanding the benefits and risks associated with weight loss medications. “The risk-benefit calculus is different for someone who may be morbidly obese compared to someone using these medications for recreational weight loss,” Dr. Sodhi concluded.

Taking proactive measures regarding nutrition and health can help mitigate the side effects of medications like semaglutide while still achieving successful weight loss.