Top 7 Medications and Supplements to Avoid Mixing with NAD+ for Your Health

Nicotinamide adenine dinucleotide (NAD+) is a vital compound naturally found in the body, crucial for various processes including metabolism, immunity, and DNA repair. As we age, studies indicate that our levels of NAD+ decline, which is linked to age-related diseases such as diabetes, heart disease, and neurodegenerative conditions like Alzheimer’s. Hence, many individuals are turning to NAD+ supplements to potentially counteract these effects.

However, it’s essential to approach NAD+ supplementation carefully, particularly if you are on medication for chronic diseases, as NAD+ levels can significantly influence how certain medications work. Here, we outline key medications that should not be mixed with NAD+ supplements.

1. Insulin and Other Blood Sugar-Lowering Medications

NAD+ supplements may interact adversely with diabetes management medications, including insulin and drugs like Fortamet (metformin). Some research indicates:

• High doses of nicotinamide (NAM), a precursor of NAD+, may decrease insulin sensitivity, leading to insulin resistance.
• This could result in a spike in blood sugar levels, potentially undermining the effectiveness of blood sugar-lowering medications.
• In animal studies, NAM has been shown to contribute to glucose intolerance, exacerbating high blood sugar levels.

2. Blood Pressure Lowering Medications

Taking NAD+ boosters can enhance the effects of medications designed to lower blood pressure. Notably:

• Higher doses of NAD+ supplements (over 2 grams daily) may significantly reduce blood pressure.
• Monitoring blood pressure while using NAD+ supplements is crucial, particularly for individuals susceptible to hypotension.

3. Cancer Treatments

There are concerns surrounding the interaction between NAD+ supplements and cancer treatments:

• Some studies suggest that NAD+ can serve as an energy source for cancer cells, possibly hindering treatment efficacy.
• Elevated NAD+ levels can lead to resistance against cancer therapies.
• If undergoing chemotherapy, it is advisable to avoid NAD+ supplements; always consult a healthcare professional first.

4. Blood Thinners

Individuals taking anticoagulants like Coumadin (warfarin) should exercise caution with NAD+ boosters:

• NAD+ boosters such as niacin may influence the metabolism of blood thinners.
• It is wise to alternate the timing of taking these medications to minimize interactions, ideally allowing at least two hours between doses.
• Monitoring the International Normalized Ratio (INR) is critical to assess blood clotting time and bleeding risk.

5. Antioxidants

Antioxidants like quercetin and resveratrol can enhance NAD+ levels in the body. However:

• While beneficial, they may also amplify the side effects associated with NAD+ supplements.
• Side effects could include hot flashes, headaches, nausea, skin irritations, and abdominal discomfort.

6. Antidepressants

For individuals on antidepressants, caution is advised when considering NAD+ supplements:

• Some antidepressants may affect NAD+ production in the body.
• Research has shown that low NAD+ levels can contribute to depression and anxiety.
• Consult a healthcare provider for guidance before combining NAD+ boosters with antidepressants, as the interaction can differ greatly.

7. Melatonin

The relationship between NAD+ supplements and melatonin is notable, as both impact circadian rhythms:

• Taking both together, particularly at night, may lead to increased sleepiness, disturbing your sleep cycle.

When to See a Healthcare Provider

The current understanding of the safety, side effects, and potential interactions of NAD+ supplementation remains limited, particularly regarding long-term effects. Here are a few guidelines:

• Pregnant or breastfeeding individuals and children should avoid NAD+ supplements due to insufficient safety studies.
• If you have existing health issues such as hypertension, cancer, or hyperglycemia, it’s crucial to consult your healthcare provider before starting NAD+ boosters.

A Quick Review

NAD+ boosters may offer support for heart health, aid in mitigating the effects of aging, and enhance muscle strength. However, potential interactions with medications such as insulin, anticoagulants, and chemotherapy must be carefully managed. To fully understand how NAD+ supplements can fit into your health regimen, consult with your healthcare provider to ensure safe practices.