Unlock Youthful Skin: Dermatologists Weigh In on How Estrogen Cream Fights Wrinkles and Dryness

Are you considering using estrogen creams to combat the signs of aging such as wrinkles and dryness? These skincare products have garnered significant attention, especially among women experiencing menopause, due to their potential role in improving skin health. However, it’s important to understand their benefits, potential risks, and what the experts say before incorporating them into your skincare routine.
Estrogen creams have traditionally served as a hormone replacement therapy for alleviating menopause symptoms, but more recently, they’ve entered the skincare arena, positioned as solutions for age-related skin concerns.
Across platforms like TikTok, both influencers and healthcare professionals are discussing the efficacy of estrogen creams. Many claim these products can:
- Reduce the appearance of wrinkles
- Add moisture to the skin
- Boost collagen production
One such influencer, Chalene Johnson, mentioned in a viral TikTok video, “If you’re trying to make your skin look more youthful, get yourself some estrogen cream.” With such enthusiastic testimonials, it might be tempting to try estrogen cream for aging skin. However, experts urge caution and call for more research.
While preliminary studies suggest that estrogen creams could be beneficial, experts emphasize that more long-term investigations are necessary to fully understand their safety and effectiveness. Dr. Kristina Collins, a board-certified dermatologist, states, “Long-term clinical trials on safety and efficacy are limited. And most research focuses on prescription estrogen, rather than over-the-counter options.”
What Are Estrogen Skincare Creams?
Estrogen creams designed for skin care fall into two main categories:
- Vaginal creams that are typically prescribed for treating symptoms of menopause such as hot flashes and vaginal dryness.
- Anti-aging creams developed specifically to combat age-related skin concerns.
The vaginal creams generally contain estradiol, the active form of estrogen, and sometimes additional types of estrogens. In contrast, anti-aging formulations may feature various ingredients such as:
- Estradiol
- Estriol
- Plant-based phytoestrogens like genistein (found in soy) or resveratrol (from grapes and berries)
According to Collins, these ingredients aim to restore estrogen’s beneficial effects on the skin, which can include:
- Boosting collagen production
- Improving skin hydration
- Enhancing skin elasticity
The concentration of hormones in these anti-aging creams is typically lower than what you’d find in vaginal creams, designed to address skin-specific concerns without significant systemic effects.
Who Should Use Estrogen Skincare Creams?
Estrogen skincare creams are primarily marketed to women in the perimenopausal and postmenopausal stages, as they often experience hormonal changes that affect skin quality. Dr. Marianna Blyumin-Karasik explains, “As we go through perimenopause, our estrogen level in skin declines, which increases dryness and impairs skin barrier function.” Using estrogen to replace what’s lost can potentially counteract some of these effects.
However, it’s essential to exercise caution when using products that alter natural hormone levels, as side effects may arise. Dr. Collins warns, “Even though absorption is lower than oral estrogen, applying estrogen creams can lead to systemic effects like breast tenderness or changes in hormone-sensitive tissues.” Therefore, you should avoid these creams if you:
- Are younger and have normal estrogen levels
- Have a history of hormone-sensitive conditions such as breast or uterine cancer
- Have a blood clotting disorder
Are Estrogen Creams Effective for Anti-Aging?
While vaginal estrogen creams have been proven effective for treating women’s health issues, the effectiveness of anti-aging estrogen creams is still under investigation. Current research on these creams is limited, often lacking rigorous controls, and results can vary significantly between products. According to Dr. Collins, “These creams are often poorly regulated, making their efficacy and safety unpredictable.”
Some studies show promise for the anti-aging effects of estrogen. For instance:
- A 2001 study indicated that applying estrogen to the face increased hydration by boosting hyaluronic acid levels.
- A 2003 study involving 65 participants found that estradiol cream was more effective than a glycolic acid cream in thickening the skin’s outer layer.
- A more recent 2018 study noted that estrogen-deficient women using a “cosmeceutical” with estrogen experienced improvement in skin dryness and atrophy compared to a control group.
Dr. Blyumin-Karasik characterized these findings as “moderate and optimistic,” but cautioned that estrogen creams may not be the first choice for treating signs of aging. Other well-established products like retinols, alpha and beta-hydroxy acids, and antioxidants like vitamin C are often preferred.
If you’re considering estrogen creams, prioritize products that have been third-party tested for quality and safety. And, as always, consult your doctor before starting any new skincare treatment, especially when hormones are involved.